Laser Scanning Confocal Microscope | SIMTRUM Photonics Store

This technology is widely adopted in scientific and industrial, for life science, material, or semiconductor  inspection. However, the cost of the mature commercialized system is usually very high.

SIMTRUM see the needs of the customer to have a robust confocal microscope system with reasonable cost. Our SIMSCOP P Series offers a great balance between functionality, cost, and flexibility. 

Key Advantage

● Professional software UI with great features for imaging analysis 

● Single or Multi laser Channel, laser power control accuracy up to 0.01%,

● Silicon PMT detector enabling higher photon dynamic range and less noise.

● Support high-speed scanning: 30fps@512x512 Pixels(Resonant scanner)

● Compact Modular design, able to adapt to most microscope system 

● Multiple upgrade options for future capability expansion with low cost 

Product Brochure Link: 

Standard Wavelength：

405nm/488nm/561nm/640nm(638nm)

Optional Wavelength

UV：375 nm

VIS：445nm/473nm/515nm/525nm/532nm

         /633nm/660nm/685nm

NIR：785nm/808nm

6 Channel Laser module is optional

Silicon PMT Detector Enabling Higher QE and Less Noise

SIMSCOP CM Series confocal microscope equipment with SiPM Detector 

● Low-voltage operation

● Long operating life,

● Wider dynamic range

● Insensitivity to the magnetic field 

● Suitable for High-speed and High-SNR imaging

Upgrade to Fluorescence lifetime imaging microscopy (FLIM) 

FLIM is a type of microscopy that allows for the visualization and analysis of biological samples based on the fluorescence lifetime of the fluorophore being used. FLIM measures the time between the excitation and emission of photons in a sample, which can provide information about the properties of the fluorophore and the environment in which it is located.

FLIM can be used to study a wide range of biological processes, including protein-protein interactions, enzyme activity, and ion concentration changes. It is often used in combination with other imaging techniques, such as confocal microscopy, to provide more detailed information about the sample.

Upgrade to Single / Two /Multi Photon Microscope

In two-photon microscope, a laser emits light at a specific wavelength that is absorbed by the fluorescent molecules in the sample. When two photons of this light are absorbed simultaneously, they provide enough energy to excite the fluorescent molecule and cause it to emit light at a longer wavelength, which can be detected by the microscope. Because two photons are required to excite the molecule, the probability of fluorescence emission is low and only occurs at the focal point of the microscope, allowing for high-resolution imaging and greater depth than conventional microscopes.

Two-photon microscopy has a number of applications in neuroscience, biology, and biomedical imaging. For example, it has been used to study the activity of individual neurons in the brain, visualize the structure and function of blood vessels, and track the behavior of cells in living tissues.

Upgrade to Confocal Spectral Microscope (Near IR I/II Confocal)

● Upgrade to Confocal Spectral Microscope (NIR I/II confocal)

● Wavelength Range UV to NIR (200nm-2.5nm)

● Spectral resolution up to 0.2nm

● Large NA setup for high-sensitivity application

Details Click here

Upgrade to High Speed Lines Scan Confocal Microscope

● Frame Rate 210fps 

● Resolution: 150 nm over the optical diffraction limit

● Imaging Depth of 500 to 1000 microns 

● Image Contract enhancement 20-30 dB

Click Here for More Info

Upgrade to Terahertz Confocal Microscope System

● 100GHz, output power: 80mW

● Spatial resolution 150-200um

The terahertz confocal microscope uses a focused beam of terahertz radiation to scan the sample being analyzed. This beam is then reflected back and collected by a detector, which creates an image of the sample based on the intensity of the reflected radiation. By using a confocal design, this microscope can achieve high resolution and can selectively focus on different depths within a sample.

 it can be used to study the microstructure and properties of materials, such as polymers, ceramics, and semiconductors, and to detect defects or anomalies in their structures. In biology and medicine, it can be used to image and study biological tissues, including skin, teeth, and cartilage, which are transparent to terahertz radiation.

Upgrade to Super Resolution Confocal Re-scan Structure illumination Microscope

A "re-scan" confocal microscope is a type of confocal microscope that uses a rapidly moving mirror or scanner to scan the laser beam across the sample multiple times, producing even higher resolution and better contrast images than standard confocal microscopes.

Overall, re-scan confocal microscopes are very powerful tools for studying biological tissues, cells, and other samples, and are widely used in research labs, medical facilities, and other scientific settings

Compatible with SIMTRUM Cryostat to perform Low-temperature Raman measurements -190 to 600 degrees

● 8 probe arm able to upgrade to adjustable probe arm

● Reflection or transmission mode available

Drosophila brain; triple antibody staining:

Alexa 488, Alexa 568 and Alexa 633

Confocal micrograph of Arabidopsis thaliana (thale cress)

Seeding leaf with stomata(yellow moth-like structures)

And parenchyma cells.

Glioblastoma cells in culture transfected with a green fluorescent protein. The nuclei are stained blue with DAPI. The red spots are 0.02-micron fluorescent spheres that have been taken up into the cells by endocytosis. These cells have no endogenous P10 protein; P10 is a tumor suppressor gene that is mutated in many different types of cancer. The absence of the P10 protein is thought to increase cell mobility and possibly contribute to metastasis.

Shown is a confocal microscope image of a human gingival fibroblast in culture. Interphase microtubules (green) are labeled with alpha/beta-tubulin primary antibodies. FITC conjugated secondary antibody was applied afterward. Nuclear DNA (blue) was stained with Hoechst33242.

Live mitotic HeLa cell treated with epsin1 siRNA, DiOC6(3)to label mitotic membranes (green). Confocal images were taken at 0.118 μm steps along the Z-axis.

Pollen grain-3D

405/445/488

/525/561/640(nm)

405/445/488/

525/561/640(nm)

405/488/561/

640(nm)

405/445/488/

525/561/640(nm)

405/488/561/

640(nm)

405/445/470/520/

528/555/640(nm)

405/445/470/520/

528/555/640(nm)

405/445/470/520/

528/555/640(nm)

405/445/470/520/

528/555/640(nm)

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Upright 

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Z Motorized

XY Manual

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